"The mind is a compact, multiply connected thought mass with internal connections of the most intimate kind. It grows continuously as new thought masses enter it, and this is the means by which it continues to develop."

Bernhard Riemann On Psychology and Metaphysics ca. 1860

"It is clear that the minds are the most important part of the universe, and that everything was established for their sake; that is, in choosing the order of things, the greatest account was taken of them; all things being arranged in such a way that they appear the more beautiful the more they are understood."

G. W. Leibniz

Today's Elites

Saturday, October 21, 2017

The birth of a new protein and the genius of Leibniz

Here is a remarkable insight from one of the authors of the paper "Foldability of a Natural De Novo Evolved Protein": "Not having emerged as this glorious work of art makes it more believable that these protein-coding genes are popping up out of the genetic region between genes," Cordes said. "I want to know where things come from in life - how life creates novelty, how evolution creates novelty."

Add this innate creative capacity to Leibniz' perspective of monads with windows upon the universe. At that point you have something that is very much like artistic composition where apparently fixed elements of musical intervals or rhythmic versification allow an infinite array of potential de novo experiments establishing harmony. This is what Leibniz meant by pre-established harmony as the best of all possible worlds.

Possible shapes for the yeast protein Bsc4 that the computer algorithm QUARK predicted using only the protein’s amino acid sequences. (Image: Matthew Cordes, using UCSF Chimera molecular graphics package)

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