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Friday, November 27, 2009

Riemann surface and biological functions

The Riemann surface models a complex function that has multiple values on sheets connected through functional branch points. Compare that with this functional diagram of the simplest of protein life forms and once again it is clear that Riemann's geometric epistemology was prescient.



This image represents the integration of genomic, metabolic, proteomic, structural and cellular information about Mycoplasma pnemoniae in this project: one layer of an Electron Tomography scan of a bottle-shaped M. pneumoniae cell (grey) is overlaid with a schematic representation of this bacterium's metabolism, comprising 189 enzymatic reactions, where blue indicates interactions between proteins encoded in genes from the same functional unit. Apart from these expected interactions, the scientists found that, surprisingly, many proteins are multifunctional. For instance, there were various unexpected physical interactions (yellow lines) between proteins and the subunits that form the ribosome, which is depicted as an Electron microscopy image (yellow). Credit: Takuji Yamada /EMBL

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