Thingumbobesquire -- Abandon All Axioms Ye Who Enter Here: The Progressive Subsumption of Cellular Process by Higher Life Forms

Sunday, June 09, 2013

The Progressive Subsumption of Cellular Process by Higher Life Forms

The recent startling discovery that cilia act as antenna for cell signalling leads to a refinement of Leibniz' principle of lower and higher monads and Vernadsky's principle of evolution.

The Leibnizian concept of a window on the world coheres precisely with this discovery. That is to say that cellular signalling via these cilia are in fact just such a window in other words.

If you then add Vernadsky's principle of ordered development of the biosphere, it is quite striking to envision that higher life forms have subsumed these same processes within their organisms. And finally human life alone is capable of making this same principle conscious through science.

From the open access report:

TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium

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By the blue taper's trembling light,

No more I waste the wakeful night,
Intent with endless view to pore
The schoolmen and the sages o'er:
Their books from wisdom widely stray,
Or point at best the longest way.
I'll seek a readier path, and go
Where wisdom's surely taught below.

How deep yon azure dyes the sky,
Where orbs of gold unnumber'd lie,
While through their ranks in silver pride
The nether crescent seems to glide!
The slumbering breeze forgets to breathe,
The lake is smooth and clear beneath,
Where once again the spangled show
Descends to meet our eyes below.
The grounds which on the right aspire,
In dimness from the view retire:
The left presents a place of graves,
Whose wall the silent water laves.
That steeple guides thy doubtful sight,
Among the livid gleams of night.
There pass, with melancholy state,
By all the solemn heaps of fate,
And think, as softly-sad you tread
Above the venerable dead,
'Time was, like thee they life possess'd,
And time shall be, that thou shalt rest.'

Those graves, with bending osier bound,
That nameless heave the crumbled ground,
Quick to the glancing thought disclose
Where Toil and Poverty repose.

The flat smooth stones that bear a name,
The chisel's slender help to fame,
Which, e'er our set of friends decay,
Their frequent steps may wear away,
A middle race of mortals own,
Men half-ambitious, all unknown.

The marble tombs that rise on high,
Whose dead in vaulted arches lie,
Whose pillars swell with sculptured stones,
Arms, angels, epitaphs, and bones;--
These (all the poor remains of state)
Adorn the rich, or praise the great;
Who while on earth in fame they live,
Are senseless of the fame they give.

Ha! while I gaze, pale Cynthia fades,
The bursting earth unveils the shades!
All slow, and wan, and wrapp'd with shrouds,
They rise in visionary crowds,
And all with sober accent cry,
'Think, mortal, what it is to die!'

Now from yon black and funeral yew,
That bathes the charnal-house with dew,
Methinks I hear a voice begin;
(Ye ravens, cease your croaking din,
Ye tolling clocks, no time resound
O'er the long lake and midnight ground!)
It sends a peal of hollow groans,
Thus speaking from among the bones:

'When men my scythe and darts supply,
How great a king of fears am I!
They view me like the last of things:
They make, and then they dread, my stings.
Fools! if you less provoked your fears,
No more my spectre-form appears.
Death's but a path that must be trod,
If man would ever pass to God:
A port of calms, a state of ease
From the rough rage of swelling seas.

Why, then, thy flowing sable stoles,
Deep pendent cypress, mourning poles,
Loose scarfs to fall athwart thy weeds,
Long palls, drawn hearses, cover'd steeds,
And plumes of black, that, as they tread,
Nod o'er the 'scutcheons of the dead?

Nor can the parted body know,
Nor wants the soul these forms of woe:
As men who long in prison dwell,
With lamps that glimmer round the cell,
Whene'er their suffering years are run,
Spring forth to greet the glittering sun:
Such joy, though far transcending sense,
Have pious souls at parting hence.
On earth, and in the body placed,
A few, and evil years, they waste:
But when their chains are cast aside,
See the glad scene unfolding wide,
Clap the glad wing and tower away,
And mingle with the blaze of day!'

Thomas Parnell

For Annie

Thank Heaven! the crisis-
The danger is past,
And the lingering illness
Is over at last-
And the fever called "Living"
Is conquered at last.

Sadly, I know
I am shorn of my strength,
And no muscle I move
As I lie at full length-
But no matter!-I feel
I am better at length.

And I rest so composedly,
Now, in my bed
That any beholder
Might fancy me dead-
Might start at beholding me,
Thinking me dead.

The moaning and groaning,
The sighing and sobbing,
Are quieted now,
With that horrible throbbing
At heart:- ah, that horrible,
Horrible throbbing!

The sickness- the nausea-
The pitiless pain-
Have ceased, with the fever
That maddened my brain-
With the fever called "Living"
That burned in my brain.

And oh! of all tortures
That torture the worst
Has abated- the terrible
Torture of thirst
For the naphthaline river
Of Passion accurst:-
I have drunk of a water
That quenches all thirst:-

Of a water that flows,
With a lullaby sound,
From a spring but a very few
Feet under ground-
From a cavern not very far
Down under ground.

And ah! let it never
Be foolishly said
That my room it is gloomy
And narrow my bed;
For man never slept
In a different bed-
And, to sleep, you must slumber
In just such a bed.

My tantalized spirit
Here blandly reposes,
Forgetting, or never
Regretting its roses-
Its old agitations
Of myrtles and roses:

For now, while so quietly
Lying, it fancies
A holier odor
About it, of pansies-
A rosemary odor,
Commingled with pansies-
With rue and the beautiful
Puritan pansies.

And so it lies happily,
Bathing in many
A dream of the truth
And the beauty of Annie-
Drowned in a bath
Of the tresses of Annie.

She tenderly kissed me,
She fondly caressed,
And then I fell gently
To sleep on her breast-
Deeply to sleep
From the heaven of her breast.

When the light was extinguished,
She covered me warm,
And she prayed to the angels
To keep me from harm-
To the queen of the angels
To shield me from harm.

And I lie so composedly,
Now, in my bed,
(Knowing her love)
That you fancy me dead-
And I rest so contentedly,
Now, in my bed,
(With her love at my breast)
That you fancy me dead-
That you shudder to look at me,
Thinking me dead.

But my heart it is brighter
Than all of the many
Stars in the sky,
For it sparkles with Annie-
It glows with the light
Of the love of my Annie-
With the thought of the light
Of the eyes of my Annie.

Edgar Allan Poe

ODE TO THE WEST WIND.

This poem was conceived and chiefly written in a wood that skirts the Arno, near Florence, and on a day when that tempestuous wind, whose temperature is at once mild and animating, was collecting the vapours which pour down the autumnal rains. They began, as I foresaw, at sunset with a violent tempest of hail and rain, attended by that magnificent thunder and lightning peculiar to the Cisalpine regions.

The phenomenon alluded to at the conclusion of the third stanza is well known to naturalists. The vegetation at the bottom of the sea, of rivers, and of lakes, sympathises with that of the land in the change of seasons, and is consequently influenced by the winds which announce it.
SHELLEY

I.
O, WILD West Wind, thou breath of Autumn's being,
Thou, from whose unseen presence the leaves dead
Are driven, like ghosts from an enchanter fleeing,
Yellow, and black, and pale, and hectic red,
Pestilence-stricken multitudes: O, thou,
Who chariotest to their dark wintry bed
The winged seeds, where they lie cold and low,
Each like a corpse within its grave, until
Thine azure sister of the spring shall blow
Her clarion o'er the dreaming earth, and fill	10
(Driving sweet buds like flocks to feed in air)
With living hues and odours plain and hill:
Wild Spirit, which art moving every where;
Destroyer and preserver; hear, O, hear!
II.
Thou on whose stream, 'mid the steep sky's commotion,
Loose clouds like earth's decaying leaves are shed,
Shook from the tangled boughs of Heaven and Ocean,
Angels of rain and lightning: there are spread
On the blue surface of thine airy surge,
Like the bright hair uplifted from the head	20
Of some fierce Mænad, even from the dim verge
Of the horizon to the zenith's height
The locks of the approaching storm. Thou dirge
Of the dying year, to which this closing night
Will be the dome of a vast sepulchre,
Vaulted with all thy congregated might
Of vapours, from whose solid atmosphere
Black rain, and fire, and hail will burst: O, hear!
III.
Thou who didst waken from his summer dreams
The blue Mediterranean, where he lay,	30
Lulled by the coil of his crystalline streams,
Beside a pumice isle in Baiæ's bay,
And saw in sleep old palaces and towers
Quivering within the wave's intenser day,
All overgrown with azure moss and flowers
So sweet, the sense faints picturing them! Thou
For whose path the Atlantic's level powers
Cleave themselves into chasms, while far below
The sea-blooms and the oozy woods which wear
The sapless foliage of the ocean, know	40
Thy voice, and suddenly grow grey with fear,
And tremble and despoil themselves: O, hear!
IV.
If I were a dead leaf thou mightest bear;
If I were a swift cloud to fly with thee;
A wave to pant beneath thy power, and share
The impulse of thy strength, only less free
Than thou, O, uncontroulable! If even
I were as in my boyhood, and could be
The comrade of thy wanderings over heaven,
As then, when to outstrip thy skiey speed	50
Scarce seemed a vision; I would ne'er have striven
As thus with thee in prayer in my sore need.
O! lift me as a wave, a leaf, a cloud!
I fall upon the thorns of life! I bleed!
A heavy weight of hours has chained and bowed
One too like thee: tameless, and swift, and proud.
V.
Make me thy lyre, even as the forest is:
What if my leaves are falling like its own!
The tumult of thy mighty harmonies
Will take from both a deep, autumnal tone,	60
Sweet though in sadness. Be thou, spirit fierce,
My spirit! Be thou me, impetuous one!
Drive my dead thoughts over the universe
Like withered leaves to quicken a new birth!
And, by the incantation of this verse,
Scatter, as from an unextinguished hearth
Ashes and sparks, my words among mankind!
Be through my lips to unawakened earth
The trumpet of a prophecy! O, wind,
If Winter comes, can Spring be far behind?	70

Thingumbobesquire -- Abandon All Axioms Ye Who Enter Here

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Sunday, June 09, 2013

The Progressive Subsumption of Cellular Process by Higher Life Forms

TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium

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The Tyrant

THIS LIVING HAND

A NIGHT-PIECE ON DEATH

By the blue taper's trembling light,

For Annie

ODE TO THE WEST WIND.