Cosmic Turbulence, Cellular Memory, Self Similarity, and Monads

When one starts from the standpoint of both Kepler and Einstein that the creation is not a random magical formula, but instead an ordered sequence of potential continuing causality that evolves, it comes as no surprise that Leibniz' principle of a harmonic subsumption of monads is being forever discovered across all self similar scales of the universe.

So, the positing of a mechanism of magnetic turbulence that enables the development of singularities of star formation to proceed at the very large astrophysical scale should be viewed as a quality that the universe evolves with a sort of beneficial fitness that in the end makes human creative reason possible. This is equivalent Kepler's idea that he was revealing the mind of God in the laws of solar system gravitation. Einstein's laws of relativity precisely proceed along this vector as well.

Likewise, the search for a physical mechanism that underlies cellular memory of genetic reproduction reminds us that Leibniz' proof that there are orders of sovereign monads at all scales not  necessarily possessing their own version of a window on the world, but capable of acting as such, is the sort of conception that should govern true scientific investigation. Indeed, contrary to the rabid outlook of misanthropes, once again, these endeavors based upon a mission to uplift the level of general well being of humanity, provide further proof, though none is needed, that we are capable of continuously improving our practice in this the best of all possible worlds.

Alexander Hamilton Comments on the Case of Edward Snowden

“Safety from external danger is the most powerful director of national conduct. Even the ardent love of liberty will, after a time, give way to its dictates. The violent destruction of life and property incident to war, the continual effort and alarm attendant on a state of continual danger, will compel nations the most attached to liberty to resort for repose and security to institutions which have a tendency to destroy their civil and political rights. To be more safe, they at length become willing to run the risk of being less free.”

Benjamin Franklin Comments on the Case of Edward Snowden

 "They who can give up essential liberty to obtain a little temporary safety, deserve neither liberty nor safety."

For Unto Us an Oligarch is Born

The rather vulgar mentality of being rich per se is but a pale imitation of your honest to goodness oligarch. Take the disgusting spectacle we endure from the cretins in the “infotainment” business gurgling and cooing over that monstrous relic of feudalism–the royal baby. He, whose thoroughly evil granddad Prince (of darkness) Phillip is wont to confess at the drop of a commoner’s hat that his most ardent desire is to be reincarnated as a deadly virus to cull the herd of the undesirables that are overpopulating his game preserves.

What kind of cult member must this otherwise normal seeming citizen in the news media be, I ask you? I think surely it must be of a zombie apocalyptic type so embraced these days. If Rip Van Winkle having been roused from his bowling match slumber these few centuries later, I’m sure he would perceive there having been no Revolution at all. King George redux and all bow down, old chap. A spot of tea?

If the People Telling Us What the "News" Is Were Merely Sane

If the people telling us what the "news" is were merely sane, we would not be expected to share their inane delight in shameless and embarrassing fawning over a relic of feudalism: a royal heir's birth. Instead we would be heralding a little noticed, yet potentially earth shattering scientific accomplishment which must have that royal extreme misanthrope chewing the rug (I mean the Queen's consort his royal heinous "I want to be reincarnated as a deadly virus to depopulate the globe" Prince (of darkness) Phillip. One billion people may have been rescued just now from the pestilential scourge of intestinal hookworm. A medical research team from the University of California, San Diego, La Jolla, CA has discovered an inexpensive treatment for this unnecessary plague that is insidiously and indiscriminately killing children through simple lack of sanitation in the most impoverished nations on this crisis ridden planet. These children's well being should be the subject of our paeans, for they are the proverbial "least of these" wherewith our moral fitness to survive will be adjudged, will we nil we. 

If we were not consumed by the besotted clown show daily regurgitated by a scandal mongering media, we might have noticed a salvo that nearly met its mark just yesterday in the House of Representatives: the amendment by Rep. Amash to prevent the NSA from unconstitutionally storing digital records on every American. 

And if we were not so deranged into the infantile make believe world that the love of money is a respectable career path, we would see the handwriting on the wall in the case of the merciless looting pension grab in the Detroit bankruptcy by the City of London royal financiers and their junior lapdog minions on Wall Street. Instead of woefully wringing our hands like a hapless chorus in classical Greek dramas over the "bail in" in Cyprus, we would take up arms and oppose these latter day oligarchs and end the reign of terror of a royal blot on human history and give to our modern day Caesars what they so richly deserve-- ignominious fall from power to do grievous harm to our most vulnerable citizens. 

The Erinyes of Clytaemnestra pursue Orestes. 

Beside Athena, who presides the court, sits Apollo. 

Engraving from G. Schwab's Die schönsten Sagen, 1912

The Detroit Bankruptcy and the Cyprus Bail In

If dear reader you can comprehend why these two events separated by an ocean are in essence about the same systemic monetary collapse that the world is presently in the midst of, then you are head and shoulders above the sycophantic con artists known as academic economists these days. Please support the return of the late great Franklin Delano Roosevelt's Glass Steagall legislation.

More Good News Published this Week in Biophysics Research

The quiet accumulation of more and more evidence for Bernoulli's magnificent ordering principle of  least action in the biophysical realm is lawfully astonishing. This illustration for instance encapsulates the engine of cellular reproduction's ordering in the endoplasmic reticulum:

The geometry here is obviously reminiscent of a minimal surface the study of which Karl Gauss pioneered.

Another tantalizing hint of the ubiquity of solitonic biophysical phase space is introduced in the discovery of how myelin sheaths are generated along axons.

In particular, the notion that a torque is transmitted along the assemblage that enable this generation is very much in keeping with a model of a standing solitonic wave function.

Red spot on Jupiter.

The Fundamental Difference Between Edward Snowden and Benedict Arnold

The title of this post should induce a train of thought that cuts through the current soap opera circus exhibited by our press. If you consider that it was none other than Benjamin Franklin who stated that "No tyrannical society can long exist when it cannot control the flow of information," then the point of the comparison becomes more clear.

For we certainly are living in a controlled environment of "infotainment" as nightmarishly noxious in essence as any dystopia cooked up by the adherents of the Anglo Dutch East Indies conglomerate such as Jeremy Bentham, H.G. Wells, Bertrand Russell, or George Orwell.

But the most dangerous enemy of the great mission which established our liberty is shining a light upon the treachery which has nearly now extinguished that selected role of Franklin, Lincoln, and FDR. For since the creation of the proxy warfare we have been embroiled in by the would be Anglo Dutch elites and the creeping take down of our commitment to Eleanor Roosevelt's conception of human rights our citizenry has collectively turned and looked the other way and going along to get along.  But the time for living by the rationale of such a deal with the devil is fast subsiding dear readers.

Vernadsky, the Heliosphere, and Astrobiology

Perhaps it is possible that the very type of heliosphere surrounding a star's planetary system will be found to be another component of the habitability of one or more of its planets due to the protection afforded life forms from cosmic rays. This would extend the sort of nested evolutionary sequence of inter-relationships that Vladimir Vernadsky pioneered to heliosphere, lithosphere, biosphere, and noosphere.

This way of looking at evolution is in keeping with the true founder of modern scientific inquiry Nicholas of Cusa.

True Genius In the Arts is Always Due to Political Sensibility

It is of no small moment that Ludwig Beethoven angrily denounced Napoleon Bonaparte or that his one opera Fidelio was about the real life rescue of Marquis de LaFayette by his beloved wife Adrienne. Likewise, when Leonardo da Vinci writes of being persecuted by an unnamed adversary, it is not the raving of a paranoiac. Greatness in any field draws fire from a vicious and powerful subset of humanity that hates it.

If the recent revelations remove the mask from this would be oligarchy that has been hell bent on destroying the once great mission of the USA, so much the better. We, as a people, have been force fed all manner of ugliness in the name of democracy since the egregious cover up of the assassination of JFK. It is way past the time to retrieve our place in the history of governments of this planet.

Torsion of DNA and Solitons

The recent successful measurement of DNA supercoiling torsion should advance the hypothesis for biophysical solitons. The condition of living systems obtaining a condition of semi permanence within an unstable and fluctuating energetic landscape is remarkably analogous to the many types and phases of inorganic solitonic behaviors. The trick is to uncover and utilize such self organizing traits for technological advancement. For instance, it was also announced earlier this week that the vortical property of optical filaments has led to a breakthrough in fiber optic bandwidth. The fact that the form the lasers involved in this discovery takes are toroidal should strike long time readers of this blog as quite lawful.

Optical Votices from The Boston University Photonic Center

Mars as a Failed Precursor to Earth's Biosphere

It has been hypothesized recently based on geological samples that Mars once had an oxygen rich atmosphere some billion years before Earth. It is intriguing to imagine this as a platform for the emergence of a living biosphere on that planet that didn't take. In this way we might extend the principle of potential evolution into the development of planetary systems and their precursors as perhaps an ordered series of ongoing development.

I believe that this concept may gain traction in the infant field of astrobiology.

More Too Big To Jail Follies

James Clapper said he was being the "least untruthful" he could be in sworn testimony to Congress..... So, yes, he is admitting he perjured himself. I guess he's too big to jail just like HSBC is on drug money laundering. charges.

The Progressive Subsumption of Cellular Process by Higher Life Forms

The recent startling discovery that cilia act as antenna for cell signaling leads to a refinement of Leibniz' principle of lower and higher monads and Vernadsky's principle of evolution.

The Leibnizian concept of a lower monad not having a "window on the world" coheres precisely with this discovery. That is to say that cellular signaling via these cilia are in fact just such a window that higher monads utilize, in other words.

If you then add Vernadsky's principle of ordered development of the biosphere, it is quite striking to envision that higher life forms have subsumed these same processes within their organisms. And finally human life alone is capable of making this same principle conscious through science.
From the open access report:

TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium

The New Star Chamber of George W. Obama

The American revolution was brought upon this nation as a necessary and just war against the despotic tyranny of “Great” Britain, now it appears we have adopted their Star Chamber methods in the so-called FISA court.

Why Behaviorists by Definition Are Incapable of Comprehending Human Creativity

This points out, albeit only through its striking omission from these models, the fundamental differentia specifica between all animal consciousness and the truly human creative mind. Humans are uniquely capable of creating a mission to change their practices to obtain a new plateau of capability in increasing available resources by redefining and expanding them through technological innovation. Thus breaking the fixity inherent in proceeding merely deductively from past experiences like dumb beasts. In the language of mathematical physics new singularities are envisioned in the purview of distinctly human sovereign noetic mental processes.

Why Yes, President Obama, Let's Change the Subject to Economics

The following dialogue may be thought of as mere fiction. But, in essence, it is very much the undeniable truth.

Question: Do you agree that the American people have a right to expect that our government should promote the form of economic prosperity that will ensure their children'd long term well being?

Answer: Of course. That is why I was elected by them.

Question: President Franklin Delano Roosevelt enacted legislation that prevented depository institutions from engaging in financial speculation. President Bill Clinton stated that his worst mistake was signing the law that repealed that very same Glass Steagall act. The repeal effected the ability of banks to engage in extremely dangerous forms of speculation in exotic financial instruments known as derivative securities. The collapse of this market enabled these gargantuan too big to fail institutions to obtain a massive multi-billion dollar bailout by the Treasury and Federal Reserve. The current policy continues to prop up these otherwise failed institutions. At the same time the lobbyists for these financiers are calling for ever increasing levels of austerity and bailouts. Will you Mr. President support the reintroduction of Glass Steagall as the first step in reversing the control of these interests that are causing such impoverishment and suffering of the American people?

Answer: Right now the economy is healing and we are on the road to prosperity with the policies that my administration is already pursuing. Next question.

Wound Healing Research and Implications

This excellent research described below should remind us of two great pioneers in scientific epistemology. Leibniz and Riemann. To wit: Leibniz' system of pre established harmony of lesser (biological) monads that do not have a window on the world, but may have that function for higher monads and Riemann's functional concept of a multiply connected manifold (in this case a biophysical one.)

Further reflection leads one to consider on a sort of built in quality of restorative principle that hold across and among Vernadsky's doctrine of three domains of lithosphere, biosphere and noosphere. One intriguing application of restorative in the noetic manifold, for instance, is the Gestalt concept of the human mind as a sovereign evolving creative process.

Vascular endothelial cell healing a transcellular wound. Credit: Christopher Carman (Medical Xpress)—


Endothelium, heal thyself: A fresh look at this resilient, adaptable tissue

May 16, 2013 by Bonnie Prescott in Medical research


The endothelium, the cellular layer lining the body's blood vessels, is extremely resilient. Measuring just a few hundred nanometers in thickness, this super-tenuous structure routinely withstands blood flow, hydrostatic pressure, stretch and tissue compression to create a unique and highly dynamic barrier that maintains the organization necessary to partition tissues from the body's circulatory system. In instances when the barrier must be physically breached to enable immune cells to reach various regions of the body to fight infection, the endothelium cooperates with leukocytes to create openings to provide the infection-fighting cells ready access to their targets.


By and large, these ensuing "micro-wounds" are short-lived; as soon as the cells have crossed the endothelium, these pores and gaps quickly heal, restoring the system's efficient barrier function. In cases when these gaps fail to close—and leakage occurs—the results can be devastating, leading to dramatic pathologies including sepsis and acute lung injury.


The mechanism underlying this highly intuitive capability has not been well understood. Now, a research team led by Christopher Carman, HMS assistant professor of medicine in the Center for Vascular Biology Research at Beth Israel Deaconess Medical Center, using a combination of advanced fluorescence imaging and electron microscopy to monitor intracellular signaling dynamics, has amassed real-time information that shows that biomechanical signals are what sets this healing process in motion.


Described in The Journal of Cell Biology, the new findings suggest that rather than structural robustness per se, the barrier function of the endothelium relies on an enormous self-restorative capacity.


"When people talk about biomechanics, they're saying that cells are able to sense and respond to changes in force," said Carman. "In other words, it's not only hormones and chemical signals that influence cell behaviors. Cells can actually sense physical cues and thereby modulate their function."


Specifically, the new findings demonstrate that the endothelium senses an acute loss of preexisting isometric tension, and that downstream of this biomechanical signal, the ensuing recovery response generates reactive oxygen species (ROS), which are responsible for coordinating the micro-wound closure process.


Carman's previous work explored precisely how leukocytes generate vascular micro-wounds in the first place, uncovering a novel endothelial piercing activity—"invasive podosomes"—that are generated by the leukocytes. In this new paper, he hypothesized an equally active role for the endothelium in closing the pores and gaps made by the leukocytes.


To test this hypothesis, Carman's laboratory set up experimental models that mimicked acute, intense inflammation. Using dynamic time-lapse and high-resolution confocal microscopy, the investigators could see the process by which leukocytes were breaching the endothelial cell.


In the course of a 10-minute span, they observed that a single endothelial cell tolerated the passage of at least seven leukocytes directly through its body, and that within this brief period, the gaps closed, leaving no sign of the pores.


"The cell's restorative capacity was just so striking," said Carman. "But these early investigations were still inadequate to tell us how the breaches were being closed. We had to dig down to the subcellular level to understand the underlying activities and the molecular signaling mechanisms that were orchestrating these activities."


Subsequent experiments, led by co-first author Roberta Martinelli, HMS research fellow in medicine at Beth Israel Deaconess and senior scientist in the Carman laboratory, revealed that in response to micrometer-scale disruptions caused by the transmigrating leukocytes, the endothelial cells were generating unique ventral lamellipodia structures, which were then migrating to the sites of the micro-wounds to close them up.


"The ventral lamellipodia were responding to the sensation of an acute loss of preexisting isometric tension," explained Martinelli, who compares the cell to a circus tent tethered in place by strategically placed ropes and stakes.


"If you cut one of the ropes holding up the tent, two things will happen," she added. "First the part of the tent that was under tension will undergo a recoil which will lead to a relaxation, leaving one part of the tent untethered and flapping in the breeze. At the same time, the remaining sets of ropes and stakes will have to bear the extra load. In the case of the endothelial cells, this translates to a force-loading event."


Existing studies have focused almost exclusively on force loading (physical pulling or tugging on cells) as response triggers. But by using new devices, the team was able to push, prod, stretch and unstretch cells in very specific ways.


"Our experiments told us that endothelial micro-wounding is actually a tension-loss, or force-unloading, signal and that this signal cued the recovery response," added Carman. This response, he said, is fundamentally dependent on proteins, the NADPH oxidases, that can generate ROS, specifically hydrogen peroxide.


ROS are widely implicated in causing cellular, tissue and organ damage when present at excessive levels in the body. But these findings show that low levels of these molecules—when produced in discrete locations within the cell—are highly protective. "It's tempting to speculate that excess ROS causes vascular breakdown by short-circuiting the recuperative response process and creating 'white noise' that dis-coordinates and disrupts micro-wound healing," said Carman. "It appears that we've got an essential homeostatic self-repair mechanism that is completely dependent on the generation of intracellular ROS, which is the opposite of our typical thinking about ROS in cardiovascular health and disease."


"These findings suggest a new way of thinking about how to deal with pathologic breakdown of the endothelial barrier," said William Aird, HMS professor of medicine and Director of the Center for Vascular Biology Research at Beth Israel Deaconess.


"We know that a 'leaky endothelium' is a central part of the pathogenesis of a number of serious diseases, including sepsis, acute lung injury and ischemic cardiovascular diseases, as well as chronic inflammatory conditions such as diabetes and arthritis. In addition to the presence of excessive barrier insults, it now appears that leakage can result when the endothelium loses its self-restorative capacity and its dynamic reserve to heal micro-wounds," Aird said.


More information: jcb.rupress.org/co… 449.abstract Journal reference: Journal of Cell Biology Provided by Harvard Medical School

Leonardo DaVinci and Solar Flares: A Pictorial Demonstration of Creative Thought Process

Solar Flare May 12, 2013 Credit: NASA/SDO/AIA

Is It Any Wonder that the IRS is Carrying Out a Witch Hunt?

One of my ancestors fell befoul of the mass hysteria in Salem many years ago. She was not among the most unfortunate but she was incarcerated for engaging in "mischief." Now, I am not one to dismiss the use of Cabalistic magic masquerading as acceptable Euclidian mathematics in the creation and promotion of Empire by the likes of John Dee, et al. However, when citizens are directed to look under their beds, so to speak,  for "Teabagger" scoundrels and report them online as spreading "fishy" misinformation about "Obamacare" back in 2009 by the White House director of "New Media" (!), Macon Phillips, is it any wonder that supposedly "rogue" IRS agents might believe that they were only doing their civic duty by blocking "fishy" outfits from tax exemption? Indeed, when they asked for donor lists, etc. weren't they perhaps merely attempting to lure those mischievous fishy extremists so they might be enlightened by right thinking "folk"?

Remember this?--

"There is a lot of disinformation about health insurance reform out there, spanning from control of personal finances to end of life care. These rumors often travel just below the surface via chain emails or through casual conversation. Since we can’t keep track of all of them here at the White House, we’re asking for your help. If you get an email or see something on the web about health insurance reform that seems fishy, send it to flag@whitehouse.gov. "

Well, perhaps the stink of scandal coming from the nether realms of the White House these days is somewhat redolent of dead fish.