Learning and memory are fundamental brain functions affected by dietary and environmental factors. Here, we show that increasing brain magnesium using a newly developed magnesium compound (magnesium-L-threonate, MgT) leads to the enhancement of learning abilities, working memory, and short- and long-term memory in rats. The pattern completion ability was also improved in aged rats. MgT-treated rats had higher density of synaptophysin-/synaptobrevin-
positive puncta in DG and CA1 subregions of hippocampus that were correlated with memory improvement. Functionally, magnesium increased the number of functional presynaptic release sites, while it reduced their release probability. The resultant synaptic reconfiguration enabled selective enhancement of synaptic transmission for burst inputs. Coupled with concurrent upregulation of NR2B-containing NMDA receptors and its downstream signaling, synaptic plasticity induced by correlated inputs was enhanced. Our findings suggest that an increase in brain magnesium enhances both short-term synaptic facilitation and long-term potentiation and improves learning and memory functions.
Thursday, January 28, 2010
Eat your spinach! (and drink your coffee)
Posted by Thingumbobesquire at 9:41 AM
- ► 2016 (29)
- ► 2015 (30)
- ► 2014 (28)
- ► 2013 (58)
- ► 2012 (162)
- ► 2011 (218)
- Paul Volcker's Latest Incarnation
- New Ice Age Aphorisms
- Watch the Pollsters Attempt to Change the Agenda N...
- Bin Laden Embraces Green Fascism
- Universal Relative Motion and Potential Energy Pro...
- Eat your spinach! (and drink your coffee)
- "Conan Obama"
- And now for something entirely different...
- "Why are America's teens getting so fat?"
- Is President Obama Acting Fishy? (A Metaproof.)
- Tomes of Forgotten Lore
- OBAMA SAYS I WANT YOU (IN THE GRAVE)
- Behaviorists Behaving Badly
- More Krugman Dross
- Lilliputians redux
- The Vision of God in a Snowfall
- ▼ January (18)
- ► 2009 (30)
- ► 2008 (22)
- ► 2007 (16)